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10.1074/jbc.M205378200 J Biol Chem
Origin & Rise of IV Vitamin Infusion Therapy The story starts with Dr
191 In one randomized controlled trial that included 175 men with infertility, taking a supplement providing 1 gram L-carnitine and 0.5 grams acetyl-L-carnitine, as well as 725 mg fumarate, 1 gram fructose, 50 mg citric acid, 10 mg zinc, 20 mg CoQ10, 50 mcg selenium, 90 mg vitamin C, 200 mcg folic acid, and 1.5 mcg B12, twice daily improved sperm motility, semen volume, and DNA fragmentation compared with placebo after six months
Mechanistically, GHK-Cu preserved mitochondrial function by increasing mitochondrial membrane potential, alleviating age-related mitochondrial network fragmentation, shifting mitochondrial dynamics toward fusion via regulating drp-1 and fzo-1 expression, and promoting ATP biosynthesis