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Skin Repair Pathways MMP/TIMP, Collagen & Elastin (PMC, 2015) A focused review of GHK as a modulator of multiple skin regeneration pathways published in PMC confirmed that GHK-Cu stimulates both synthesis and breakdown of collagen and glycosaminoglycans, and modulates the activity of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs)

Based on available research and user experience, REGEN appears safe for cycles up to 12 weeks at standard doses

doi:10.4162/nrp.2010.4.3.229

In adults, treatment length varies based on symptom relief and IGF-1 targets, and some may use it indefinitely if benefits persist (with periodic re-evaluation)