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The highly similar pattern of microbiome alterations following GLP-1 and dual GLP-1/GLP-2 receptor agonist treatment likely associate to the biological actions of the receptors that converge at several levels with respect to regulation of energy homeostasis, gut morphology and intestinal repair 82
A diverse, balanced gut flora is associated with optimal SCFA production, which may in turn support L-cell function
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They also have shown that they could have endotoxins, which is a marker of contamination. Two-thirds of doctors polled said they were either moderately or very concerned about patient access to research peptides
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