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HDAC6 inhibitor Ricoliostat: HDAC6 inhibitors can promote the degradation of protein aggregates or protect neurons from oxidative stress, hence can be used as possible drugs for treating peripheral neuropathy

10.1002/ehf2.13024 168 TsalamandrisS.AntonopoulosA

First, it's important to note that data from human clinical trials involving ipamorelin is extremely limited

2D two-dimensional hiPSC human induced pluripotent stem cell 3D three-dimensional hPSCs human pluripotent stem cells AAV adeno-associated virus HUVECs human umbilical vein endothelial cells ADPKD autosomal dominant polycystic kidney disease iETV2-hiPSCs inducible ETV2-expressing human induced pluripotent stem cells AI artificial intelligence iPSC induced pluripotent stem cell AKI acute kidney injury NF-B nuclear factor kappa-light-chain-enhancer of activated B cells ALI air-liquid interface NGAL neutrophil gelatinase-associated lipocalin cAMP cyclic adenosine monophosphate PBMCs peripheral blood mononuclear cells CKD chronic kidney disease pFSGS primary focal segmental glomerulosclerosis CRISPR/Cas9 clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 ROS reactive oxygen species ECM extracellular matrix scRNA-seq single-cell RNA sequencing ESC embryonic stem cell TCBs T cell bispecific antibodies ESRD end-stage renal disease TGF-1 transforming growth factor beta 1 EZH2 enhancer of zeste homolog 2 VEGF vascular endothelial growth factor Glossary References 1

Similarly, IRE1 dysregulation has been observed in tauopathies, PrD, and HD, highlighting its role in neurotoxicity, whereas ATF6 dysfunction exacerbates protein aggregation and has been linked to FTD and tauopathies