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In vivo preclinical models exploring dermal repair, antifibrotic effects, neuroprotection, and pain modulation through pathways involving VEGF, TGF, miRregulated signaling, and amino acidmediated analgesia
Similarly, supplementation with Lactobacillus [79] and Bifidobacterium [87] modulated DA in the prefrontal cortex [79] and in the gut [87] as well as NA [87]
205 Currently, three major categories of SIRT1-targeted drug candidates are under investigation: natural products, synthetic small-molecule activators, and NAD + precursor supplements
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