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Weight-regulation genes like FTO rs9939609 and MC4R rs17782313 influence baseline metabolic dysfunction and appetite signaling

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Genetic mutations that inhibit MC4R signaling cause hyperphagia, decreased energy expenditure, and early-onset severe obesity, demonstrating the receptor's fundamental importance in weight regulation

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[1] Because visceral adiposity is itself linked to cardiometabolic risk, these lipid changes are biologically coherent