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Although GLP-1s primarily stimulate insulin secretion in a glucose-dependent manner (for instance, only in the presence of elevated blood glucose), hypoglycemia can still occur in certain situations such as insufficient food intake, excessive exercise, and particularly when used in combination with other antidiabetic agents, such as sulfonylureas or insulin
However, this pain was still rare: affecting only 4% of adolescents taking Saxenda vs
Key trials studied the compounds themselves STEP for semaglutide in weight management (NEJM 2021), SURMOUNT for tirzepatide (NEJM 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM 2024)
Supplemental Figures for: ERAP2 increases the abundance of a peptide submotif highly selective for the Birdshot Uveitis-associated HLA-A29
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