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SURPASS-3 MRI, a sub-study of the phase-3 SURPASS-3 trial assessed tirzepatide administered once per week versus insulin degludec on liver fat content (LFC)
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However, a clinical study demonstrated that the Treg level was negatively correlated with the severity of RE and that Treg function was impaired in RE patients, demonstrating the complex mechanism of Tregs in RE development 52
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