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If pregnancy is planned, the medication should be discontinued at least two months before attempting conception due to the long washout period of semaglutide
Case series in women with PCOS treated with peptide-guided metabolic therapy report restored menses and spontaneous conception in a subset, particularly when combined with dietary interventions and supervised exercise
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Rather than relying solely on high-dose or combination regimens, treatment decisions should be guided by a thorough evaluation of the patient's redox status, fertility profile, and response to previous therapies [71]
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