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The affected genes cluster in several functional categories directly relevant to skin biology
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The glutathione cycle: glutathione metabolism beyond the -glutamyl cycle
In the excited cell, these internal calcium ions are released, while extracellular calcium ions enter the cell.) With the increased movement of charged particles during the stimulation of a nerve or muscle, as one kind of counterion is exchanged for another, and the destruction of some of the water's structure, there are more opportunities for bulk dielectric water to enter cells, interfering with the arrangement of proteins, and tending to cause swelling and separation of the structural elements of the cell
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