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Systemic administration allows the peptide to reach distal tissues like ligaments or skeletal muscle
[1] It is investigated for its potential role in nitric oxide pathway modulation, growth factor signaling, and extracellular matrix remodeling
VEGFR 1 was confirmed to autophosphorylate at Tyr-1169, 1213, 1242, 1327 and 1333, and PI-3K is a potential candidate mediating biological effects after Tyr-1213 autophosphorylation
They have not been approved or extensively tested by the FDA for safety or how well they work for people, especially with ongoing use
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