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Although de novo polyamine synthesis from ornithine represents the major source of intracellular polyamines, transport of extracellular polyamines into cells is accomplished via the SLC45A4 encoded transporter which is a member of the glycoside-pentoside-hexuronide cation symporter family of transporters

Kanner BI et al (1979): Reserpine as a competitive and reversible inhibitor of the catecholamine transporter of bovine chromaffin granules

Ipamorelin hits the GHRP receptor and says "release GH now." CJC-1295 (no DAC) hits the GHRH receptor and says "amplify that release." When dosed together: CJC-1295 primes the pituitary and increases the available pool of GH Ipamorelin triggers the acute release of that pool The combined pulse is substantially larger than either compound generates alone research suggests synergistic effects in the range of 210x depending on baseline GH status and dosing This works because the two compounds bind to completely separate receptors

A separate narrative review titled "Regeneration or Risk?" acknowledged the promising preclinical evidence but stressed the critical need for larger human trials