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In a year-long trial involving 50 HIV-infected patients who had been treated with antiretroviral drugs for an average of six years and had developed metabolic syndrome, metformin treatment significantly slowed the rate of coronary artery calcification compared to lifestyle modification

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43 This suggests that this mtDNA mutation is a risk factor that requires interactions with nuclear mutations, polymorphisms or epigenetics and/or environmental triggers or modulators in order for the disease phenotype to be expressed

Si la barrera intestinal se daa, pueden pasar ms sustancias dainas a la sangre que activaran an ms al sistema inmune, haciendo que genere an ms anticuerpos contra la tiroides