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In addition, the accumulation of AGE in the tissues induces cellular oxidative stress and promotes inflammation, thus increasing the vulnerability of the target tissues [58]
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The addition of phenformin, a Complex I inhibitor, caused the oxphos reliant cells to switch to a glycolysis signature, highlighting the plastic nature of the oxphos reliant cells
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This review found that GSH supplementation produced modest, variable improvements in skin lightening with relatively few side effects
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