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alone, an estimated 1 in 8 adults nearly 12% of the population have reported using medications such as Wegovy (semaglutide) and Zepbound (tirzepatide)

Reporting should include discrimination (C-statistic, AUC), calibration (slope, Brier score), and clinical utility metrics (e.g., NRI, IDI, decision curve analysis) (66)

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The prior authorization guidelines are detailed in this Medicaid bulletin

For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101