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Key mechanisms include: Stimulation of collagen and elastin synthesis in fibroblasts Activation of lysyl oxidase for collagen cross-linking Enhanced production of glycosaminoglycans and decorin Modulation of metalloproteinase activity for controlled matrix breakdown The copper ion serves as an essential cofactor for enzymes involved in collagen synthesis and provides antioxidant protection through superoxide dismutase activation
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In a 68-week clinical trial studying Wegovy (2.4 mg) in patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15%, when paired with diet and exercise changes (compared to 2.4% with diet and exercise alone)
