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People with cancer or an elevated cancer risk: Growth hormone secretagogues can stimulate both cell death and cellular replication, the same biological events that preface cancer.31 Therefore, you should avoid peptides like ipamorelin and tesamorelin if youve survived cancer or have an active cancer diagnosis

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For women, this raises additional concerns about exposure during sensitive life stages (e.g., pregnancy, postpartum, perimenopause)

Inflammatory response modulation: Both peptides have been observed to affect cytokine activity and other markers of inflammation in experimental settings