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Indeed, eGFR values were greater in patients on tirzepatide compared to those on insulin glargine, with a mean eGFR decline rate of 1.4 ml/min/1.73 m 2 per year in tirzepatide users and a between-group difference in eGFR reduction of 2.2 ml/min/1.73 m 2 per year [49]

The expression of GLP-1R on various cell types and its impact on the neurovascular unit (NVU), including neurons, glial cells, and endothelial cells, make GLP-1 a strong candidate for bridging brain-body crosstalk

Data on severe hepatic impairment remains limited