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While heart palpitations specifically are not listed among the common adverse reactions in the FDA prescribing information for semaglutide products, increased heart rate is a documented effect, particularly with Wegovy

Initial testing included laboratory tests to identify abnormalities in the respiratory chain, tricarboxylic-acid cycle (TCAC) and fatty-acid oxidation pathways

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Maunder, A., Bessell, E., Lauche, R., Adams, J., Sainsbury, A., & Fuller, N

Most reported reactions overlap because both ultimately stimulate the same growth hormone release pathway