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Severe deficiency : Weekly or biweekly injections may initially be required to correct anemia and neurological symptoms
We show (i) that PfGrx-catalyzed redox reactions outcompete uncatalyzed reactions between roGFP2 and GSH or GSSG by several orders of magnitude, (ii) that the PfGrx-catalyzed reduction and oxidation of roGFP2 occur via a mono- and not a dithiol mechanism, and (iii) that the reduction of roGFP2(S 2 ) as a model non-glutathione disulfide substrate most likely involves a rate-limiting glutathionylation in a ternary complex with a GSH molecule that is activated at the 1st glutathione-interaction site of PfGrx
Lohi, H
IV and injectable therapies may also benefit those who exercise regularly, travel often, or have difficulty absorbing nutrients through oral supplements
Therefore, the use of several sub-strains of mice is a strength of this study [49, 50], and suggests that our findings are more likely to generalize to other mouse sub-strains than they would have if the study were conducted in only one strain of mice
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