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Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit
Development was terminated, and no pharmaceutical company has pursued AOD 9604 through Phase 3 trials since
Cancer Lett 336:149157
For people with type 2 diabetes, the SURPASS trial series demonstrated exceptional glycemic control alongside weight loss, which is why the compound received its first approval for diabetes before the obesity indication followed
References Wang, W
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