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Key Takeaways Studies have not shown a significant increase in pancreatitis rates among Ozempic users compared to those on a placebo, and events reported were generally mild
the tri-agonist design relies on the GLP-1 and GIP components to offset this hyperglycaemic potential
compared to a low bioavailability of 1-2% when taken orally
They also found that treatment with exenatide resulted in a marked increase in anti-inflammatory cytokines (IL-4 and IL-10) alongside a reduction in pro-inflammatory cytokines (TNF and IL-1) [65]
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