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The protocol enrolled 670 adults who completed 36 weeks of open-label tirzepatide (achieving a mean weight loss of 20.9%), then randomised them to either continue tirzepatide or switch to placebo for another 52 weeks
The same dopamine suppression that quiets cravings might flatten mood, reduce motivation, or delete the capacity for joy in someone already prone to depression
Key Points to Keep in Mind Lower-dose maintenance supports metabolic stability rather than aggressive loss
Consistency matters enormously with GLP-1 therapy because steady blood levels produce better results than erratic dosing
Building your personalized GHK-CU protocol Theory becomes useful only through application
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