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Mechanistically, it works upstream of structural damage by blocking NF-kappaB before the downstream cytokine cascade (TNF-alpha, IL-1beta, IL-6) gets going, rather than mopping up inflammation after the fact

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity [PMID: 19262508] Laboratory literature summary: AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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It is postulated that through these mechanisms, NAD+ repletion might improve cellular energy capacity and resistance to oxidative stress

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