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Dr Kormas has received honoraria for presentations from Johnson & Johnson

Some GLP-1 medications may reduce thirst or fluid intake in certain patients, while eating less can also mean getting less water from food

It most commonly occurs during the titration phase (the period during which your doctor gradually increases your dose to reach the maintenance level)

Pharmacist Tip: Always read the label, follow the dosing schedule, and inform your pharmacist or doctor about any other medicines or supplements youre taking

Retatrutide dosing protocol Retatrutide uses a different titration approach, reflecting its greater potency and triple-receptor activity: Weeks 1-4: 1 mg once weekly (starting dose) Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Week 17 onward: 8-12 mg once weekly (maintenance dose) Some trial protocols use a slightly modified schedule, escalating every four weeks with dose increases of approximately double at each step