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Both B 12r and B 12s are stable indefinitely under oxygen-free conditions
(accessed May 2022)
The evidence base is overwhelmingly preclinical, and there are no completed, published Phase 2 or 3 human efficacy trials only early-stage safety work [9]
Thomas JE, Kang S, Wyatt CJ, Kim FS, Mangelsdorff AD, Weigel FK
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