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When people lose weight, the body responds

It has also been shown to decrease oxidative stress in the eye and delay age-related changes, including loss of visual acuity and the incidence of cataracts [12]

There are also several proposed direct renal effects including 2 , 3 , 8 : 1) Reduced intraglomerular pressure by activating tubuloglomerular feedback (TGF) on the basis of acute proximal tubular natriuresis 9 - 12 leading to afferent arteriolar vasoconstriction, particularly in the setting of renal hyperfiltration 13 - 19

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It stimulates the release of growth hormone without causing a concurrent surge in hunger or elevating cortisol and prolactin levels