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The goal in the early stages is consistency, not intensity
Efficacy of GLP-1-based Therapies on MASLD and MASH: Systematic Review and Meta-analysis
N, number of participants in the semaglutide and placebo arms
Biotechnology International
When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before
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