To be honest, I was a little scared
Cardiovascular Safety : The cardiovascular safety of tirzepatide has been evaluated and confirmed to date through a pre-specified meta-analysis of phase 2 and 3 randomized trials comparing tirzepatide with other placebo, insulin glargine, degludec, semaglutide, dulaglutide for a minimum of 26 weeks (including the GPGB, SURPASS 1,2,3,4,5, and J-mono studies) [67]
These extra structures are known to be the essential determinant of sulfonamide sensitivity, as opposed to the base NH 2 -SO 2 moiety contained in all sulfonamides
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Lastly, keep in mind that most studies showing efficacy of GLP-1 agonists for weight loss usually require participants to make lifestyle modifications such as changes in diet and exercise, to control portions and eat high nutrient, low energy foods and move more while taking the medications