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these were the most frequently reported AEs across all treatment arms but they were mostly transient and mild/moderate in severity, consistent with the safety profile of the GLP-1RA drug class [8, 18, 24]
Factors such as geographic location and pharmacy choice also play a vital role in this variation
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Within minutes after a meal, GLP-1 is released from L cells in the ileum and colon, and it regulates insulin secretion in a glucose-dependent manner
The FDA-approved brand-name medications in these same drug classes are Ozempic and Wegovy (containing semaglutide, manufactured by Novo Nordisk) and Mounjaro and Zepbound (containing tirzepatide, manufactured by Eli Lilly) - all FDA-reviewed for safety, efficacy, and quality, which compounded versions are not
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