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Tatsuta Y, Kasai K, Maruyama C, et al

It is mainly found in the cytosol of cells, while MAO is found in the mitochondria.[ref] Recent studies on aggression and mood have looked at the interaction between slow COMT activity and low MAOA activity

Subsequent studies confirmed senolytic activity in additional cell types including chondrocytes, Leydig cells, keloid fibroblasts, and endothelial cells demonstrating that the FOXO4-p53 dependency is a conserved feature across multiple senescent cell populations