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Concomitantly, dysregulated GSH metabolism and impaired energy metabolism synergistically exacerbate hippocampal neuronal injury, forming a self-amplifying pathological loop (Figure 9)

Immune Response Complications : Stem cell therapy's immunomodulatory properties also bring potential complications related to immune responses, especially in allogeneic transplantation (using donor stem cells)

All these risk factors have a common characteristic, they are associated with a continuous state of oxidative stress and inflammation, excessive production of free radicals (reactive oxygen and nitrogen species) and endothelial cell dysfunction leading to cardiovascular disease and respiratory failure

doi: 10.3896/IBRA.4.01.2.02 88 Fernandez-CabezudoMJEl-KharragRTorabFBashirGGeorgeJAEl-TajiHet al