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The transition into a post-reproductive state, such as menopause or estropause, is associated with the development of a systemic pro-oxidant environment characterized by increased reactive oxygen species and diminished antioxidant defenses [146]

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A 12-week phase II trial of CJC-1295 in HIV-associated lipodystrophy reported one death from myocardial infarction, attributed by the attending physician to pre-existing coronary disease

Gastrointestinal side effects are common, especially during dose escalation

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