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Specifically, in Parkinsons disease (PD) a drop in GSH is often one of the first signs of the development of disease due to the fact that an absence of the antioxidant causes nerve damage, cell death, and oxidative stress

[36] MTHFR A1298C may play a role as either a driver in the development of major depressive disorder or as a predictive or diagnostic marker, possibly in combination with C677T

Rare but serious adverse effects include pancreatitis (though causality remains uncertain), gallbladder disease, and potential thyroid C-cell tumors (observed in rodent studies but not conclusively demonstrated in humans)

This GLP-1 drug also reduces the risk of heart attack and stroke in people with diabetes and cardiovascular disease