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However, many of these drugs are poorly tolerated and are associated with significant adverse events
They help decrease the risks of strokes, heart attacks, and death caused by cardiovascular diseases
The European Association for the Study of the Liver (EASL) clinical practice guidelines on Wilson disease note that hepatic copper exceeding 250 mcg/g dry weight is a strong diagnostic criterion for Wilson disease, but subclinical copper accumulation can begin at much lower thresholds in patients with cholestatic or cirrhotic liver disease [2]
Round, P., Priestley, A
Cochrane, 2021
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