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Support for estradiol altering insulin sensitivity has also been reported in rodents, since estradiol deficient animals are more likely to develop insulin resistance (170, 171)

Berberine should be avoided during pregnancy and breastfeeding due to potential risks including neonatal jaundice

These complications are extensive and diverse, encompassing metabolic disorders such as type 2 diabetes 2 , dyslipidemia 3 , cardiovascular diseases 4 and an increased overall mortality risk 5

For instance, MC-1R appears linked to pigmentation, MC-2R to adrenal activity, MC-3R to metabolic regulation, and MC-5R to exocrine functions such as sweating and sebum production

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