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GLP-1RAs directly stimulate POMC/CART neurons and indirectly inhibit NPY and AgRP to increase measures of satiety and decrease hunger, resulting in reduced energy intake, thereby facilitating weight loss (Ard et al., 2021) (Figure 6)
The role of glucagon in glucose intolerance and effects of GLP-1 based drugs on plasma glucagon
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Why behavior change, coaching, and structured education are critical for maintaining results beyond medication
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An important aspect of oral semaglutide is that absorption likely takes place in the stomach
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