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It is considered to belong to the Class B family of GPCRs whose members possess an extracellular N-terminal domain of 100-150 amino acids connected to the 7TM domain core typical of all G protein receptors (26)
Safety and efficacy of tapentadol ER in patients with painful diabetic peripheral neuropathy: results of a randomized-withdrawal, placebo-controlled trial
Arch Biochem Biophys 310, 273281 (1994)
doi: 10.1507/endocrj.EJ16-0109 27 SaravananPChauW-FRobertsNVedharaKGreenwoodRDayanC
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