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The fundamentals matter regardless of medication: Calorie deficit through proper nutrition High protein intake (0.7-1g per pound daily minimum) Resistance training 2-4x weekly Adequate sleep and stress management Sustainable lifestyle changes Medications like retatrutide can be powerful tools, but they work best when combined with the basics

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muciniphila in liver disease, cardiovascular disease, cognitive impairment, and aging (Grajeda-Iglesias et al., 2021)