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Concerns have been raised that the rate of DKA in real-world practice would surpass rates seen in closely supervised RCTs [37]
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Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas)
Furthermore, altered expression and activation of proinflammatory genes (eg IL-1 receptor family and genes regulating fibrotic responses ( TGF beta-1 , FGFR2 receptor 2 ) that may contribute to the development of NASH are also under the control of TH
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