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GLP-1R modulation also shows promise in epilepsy and cognitive impairment, where it may influence neurotransmitter release and exert anticonvulsant effects [312]

People with active eating disorders or a high risk of restrictive eating

Stress management The physiological and psychological changes that come with Mounjaro treatment can increase stress, potentially triggering headaches: Practice regular relaxation techniques like deep breathing or progressive muscle relaxation Consider mindfulness meditation which may help with stress reduction Incorporate gentle physical activity like walking or swimming Medication timing Working with your healthcare provider to optimise when you take Mounjaro can help: Some patients report fewer headaches when injecting their dose in the evening Others find morning administration works better, particularly if sleep disruption is an issue Maintain consistency once you find what works for you Managing existing headaches If you do develop a headache while on Mounjaro: Stay hydrated Take paracetamol or ibuprofen as directed (unless instructed otherwise) Rest in a quiet, darkened room if possible Apply a cold or warm compress to your head or neck Consider gentle neck stretches to release tension Most Mounjaro-related headaches respond well to these simple interventions

Claxton AJ, Cramer J, Pierce CA

Every fat-metabolism, NAD+, SIRT1 and lean-mass effect described above is preclinical (rodent or cell) only and should be read as a hypothesis, not an established human benefit