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Combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the weight loss and cardiometabolic benefits of GLP-1 RA [21]
Tirzepatide works by mimicking the actions of incretin hormones , which enhance insulin secretion in response to meals, suppress glucagon release, slow gastric emptying, and promote satiety
Scientific References for this article: STEP-1 Trial: Semaglutide Once Weekly for Obesity 2021 | New England Journal of Medicine SURMOUNT-1: Tirzepatide Once Weekly for Obesity 2022 | New England Journal of Medicine Predictors of Weight Loss Response to GLP-1 Receptor Agonists 2022 | Diabetes, Obesity and Metabolism Weight Loss with Semaglutide According to Baseline Characteristics 2022 | Diabetes Care Variability in Response to Anti-Obesity Medications 2023 | Nature Reviews Endocrinology Pharmacological Treatment of Obesity: Combination Strategies 2022 | Nature Medicine Review Switching Between GLP-1 Receptor Agonists 2023 | Obesity (Journal of The Obesity Society) Real-World Effectiveness of GLP-1 Agonists Across Diverse Populations 2023 | JAMA Network Open Non-Responders to GLP-1 Receptor Agonists in Obesity Management 2024 | Obesity Reviews
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