Chemosphere, 329: 138652 Payette G, Geoffroy V, Martineau C, Villemur R (2019)
For a significant impact on skin tone and clarity, a course of 8-10 injections is often recommended
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Skin Rejuvenation GHK-Cu has clinically demonstrated improvements in skin firmness, elasticity, and tone
Discard 28 days after first use, regardless of remaining volume