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These findings suggest a substantial degree of central sensitization in cirrhosis, highlighting nociplastic pain as a crucial component of chronic pain in these patients (68, 81)
Weight was measured at week 24 and again at week 48
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There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)
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