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Tonnus, W
Glutathione doesn't work in a vacuum
2025;6:1002336 DOI: Received: May 12, 2025 Accepted: August 28, 2025 Published: September 22, 2025 Academic Editor: Nicola Normanno, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Italy The article belongs to the special issue Use of Different Radiation Treatment Modalities in Cancer Therapy: The Role of Inflammation and Immune Response Aim: During radiation treatment, reactive oxygen species (ROS) and nitrogen species (RNS) are produced and, by extension, DNA adducts known as 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NG), respectively
Therefore both GST and efflux pumps overexpression may confer high levels of resistance to the cytotoxic action of several antineoplastic drugs
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