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Mitochondrial Ca 2+ uptake promotes ATP synthesis by activating components of the TCA cycle and oxidative phosphorylation (OXPHOS) supercomplexes, emphasizing the interplay between mitochondrial ATP production and Ca 2+ clearance in synaptic transmission [38]

The temptation to increase the dose beyond 2.4mg exists, but clinical data beyond that dose point is limited for weight management specifically

Nasal delivery can be appealing for patients who prefer an option that avoids both oral and injectable routes, while injections provide a more direct method of administration

Both medications require careful dosing adjustments based on individual responses and tolerability

Harbord R, Harris M, Dawson J