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The importance of the latter signaling pathway was also illustrated by other recent reports, including: a study where the novel small molecule acetonitrile derivative monepantel effectively suppressed ovarian cancer cells growth, proliferation, and colony formation by down-regulating IGF-1R and inhibiting its mTOR/p70S6K downstream target in these cells (25)
doi: 10.1038/s41588-017-0011-x 98 AkbariPGilaniASosinaOKosmickiJAKhrimianLFangYYet al
& Terman, A
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