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Preparation of DAB-stained HEK293T cells for EM LaccID-expressing cells were fixed using warm 2% glutaraldehyde in buffer (100 mM sodium cacodylate with 2 mM CaCl 2 , pH 7.4) and then quickly moved to ice

The C max values of each dose were 1.05 0.429, 3.30 0.508, and 26.1 7.82 ng/ml, respectively, and the AUC 0t values were 29.0 2.68, 160 21.0, and 830 247 ng min/mL respectively

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