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This cascade induces endoplasmic reticulum stress and mitochondrial damage in ECs, leading to apoptosis [111, 112]

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Metabolic Disorders Associated with the PPP Accumulation of reactive molecules, such as reactive oxygen and reactive nitrogen species (ROS and RNS), lipid hydroperoxides, etc

For instance, T cell infiltration caused by immunotherapy can reshape the metabolic microenvironment (such as IFN- driving IDO expression), offsetting the effect of metabolic intervention [140]

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