In preclinical models of cerebral ischemia, MSC administration significantly attenuates apoptotic cascades, neuroinflammation, and oxidative stress, while concurrently stimulating angiogenesis, endogenous neurogenesis, oligodendrocyte survival, and synaptic remodeling [22,23,24,25,26]
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Interest in such applications is largely driven by their proposed mechanisms of action, including enhancement of tissue repair, modulation of inflammation, and cytoprotective effects observed in preclinical studies